CARBOHYDRATE METABOLISM, RESPIRATION AND CIRCULATION IN ANIMALS WITH BASAL METABOLISM HEIGHTENED BY DINITROPHENOL

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Abstract
Administration of 1-2-4 dinitrophenol can increase the O2 consumption of anesthetized dogs 10 times or more, resulting in a rise in body temp. There is no notable change in the proportion of nutrients serving as fuel. Marked increases in min. volume of circulating blood and in arterial-venous O2 difference occur. Respiratory rate and tidal air increase greatly. A pre-mortal acidosis is observed with fatal doses.

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