Synthesis of Partially Fluorinated β-Amino Acids via Morita-Baylis-Hillman Reaction
- 31 December 2001
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2001 (02) , 0281-0285
- https://doi.org/10.1055/s-2001-10816
Abstract
A convenient synthesis of fluorinated β-amino acids via Morita-Baylis-Hillman reaction is described. Hydrogenation of Morita-Baylis-Hillman adducts or cuprate addition to the double bond provides ready access to α-substituted β,β-bis(trifluoromethyl) β-amino acids.Keywords
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