Stereoselective synthesis of alcohols. Part LIII. (E)-γ-Alkoxyallylboronates: generation and application in intramolecular allylboration reactions
- 29 September 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 25 (1) , 102-107
- https://doi.org/10.1039/b003551n
Abstract
Alkoxyalkynes 9 may be hydroborated with pinacol borane, preferentially under Cp2ZrHCl catalysis, to give the vinylboronates 10. The latter, when subjected to the Matteson–Brown homologation with LiCH2Cl, give rise to the (E)-γ-alkoxyallylboronates 3 in good yield. This reaction sequence has been used to generate the (E)-γ-alkoxyallylboronates 14, 21, 26 and 31, which were the starting point for intramolecular allylboration reactions leading to the trans-disubstituted tetrahydropyrans 8 and 22, as well as hydrooxepans 27 and 32.Keywords
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