TIME FACTOR IN SHIFTING OF BLOOD PRODUCED BY UNILATERAL HYPOXIA

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Abstract
In a study of patients with various lung diseases, shifting of pulmonary arterial blood flow away from the hypoxic lung may occur after only 2 min. of induced hypoxia. The decrease in flow to the hypoxic lung was 16%, about 1/2 the decrease found with 7 min. of N2 administration. Atropine, in a dose of 0.4 mg., did not prevent this reduction in flow to the hypoxic lung. In a series of 6 experiments, atropine was not administered, and the reduction of flow was 31%; this was not significantly different from the 41% decrease found in patients who were premedicated with atropine.