N‐RAS mutations in T‐cell acute lymphocytic leukaemia: analysis by direct sequencing detects a novel mutation
- 1 May 1989
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 72 (1) , 36-39
- https://doi.org/10.1111/j.1365-2141.1989.tb07648.x
Abstract
Summary. A novel mutation of the N-RAS gene of T-ALL blast cells was detected by a direct sequencing of in vitro amplified exon-1 of the N-RAS gene. Threonine (ACA) was substituted for alanine (GCA) at codon 11. This mutation would have been overlooked by conventional probe hybridization techniques. A search for other mutations in N-RAS exon-1 in T-ALL revealed a codon 13 mutation substituting aspartic acid (GAT) for glycine (GGT) in one of 18 patients. No mutations at codon 12 were detected.This publication has 21 references indexed in Scilit:
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