The synthesis of total and specific glycosaminoglycans during development of experimental liver cirrhosis
- 1 October 1977
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 33 (10) , 1290-1292
- https://doi.org/10.1007/bf01920139
Abstract
During hepatic fibrogenesis induced by long-term administration of thioacetamide, the synthsis of chondroitin 4,6-sulfate and hyaluronic acid was strongly enhanced; the formation of heparan sulfate comprising at least 70% of total liver GAG synthesis and of a keratan-sulfate-like fraction was stimulated 1.7fold. Formation of dermatan-sulfate in liver could not be detected.Keywords
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