The Influence of Choline and of Trypan Blue Upon the Utilization of Carotene and Vitamin A for Liver Storage of Vitamin A

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Abstract
The deposition of vitamin A in the livers of depleted rats fed fixed amounts of vitamin A along with high-fat low protein diets was not affected by the presence of excess liver fat or choline deficiency. With a low-fat low-protein basal diet the addition of choline increased the liver vitamin A. When carotene was fed with the high-fat diets the liver vitamin deposits were very small and were somewhat less in the fatty than in the normal livers. With the low-fat diet the carotene produced better vitamin deposition, which was little affected by the presence or absence of choline. The hepatic accumulation of vitamin A was much the same when the vitamin was fed with the high-fat and low-fat diets, regardless of liver fat, except for a slight decrease on the lard diet. When carotene was fed there was a definite depression of vitamin A storage on the high-fat as compared with the low-fat diets. The injection of trypan blue produced no effect upon the deposition of vitamin A in the livers of rats fed a fixed amount of the vitamin. A depression of doubtful significance occurred in the deposits found in similar animals fed relatively large amounts of carotene. It is concluded that the mechanisms of utilization and storage of vitamin A and carotene are probably affected by different conditions and that the composition of the accompanying vitamin-deficient basal diets is an important factor in determining their efficiency.

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