Molecularly Imprinted Uniform-Sized Polymer-Based Stationary Phase for Naproxen
- 1 June 1997
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 26 (6) , 555-556
- https://doi.org/10.1246/cl.1997.555
Abstract
A molecularly imprinted uniform-sized polymer-based stationary phase for (S)-naproxen has been prepared using 4-vinylpyridine and ethylenedimethacrylate as a host functional monomer and cross-linker, respectively. The imprinted polymer material could separate naproxen enantiomers with separation factor of 1.74. Further, the materials showed high selectivity for naproxen and moderate selectivity for other 2-arylpropionic acid derivatives. On the other hand, the imprinted polymer material showed little selectivity for other acidic, basic and neutral compounds.Keywords
This publication has 6 references indexed in Scilit:
- Enzyme-analogue built polymers and their use for the resolution of racematesPublished by Elsevier ,2001
- Molecular Imprinting in Cross‐Linked Materials with the Aid of Molecular Templates— A Way towards Artificial AntibodiesAngewandte Chemie International Edition in English, 1995
- Molecular recognition in continuous polymer rods prepared by a molecular imprinting techniqueAnalytical Chemistry, 1993
- Influence of the seed polymer on the chromatographic properties of size monodisperse polymeric separation media prepared by a multi‐step swelling and polymerization methodJournal of Polymer Science Part A: Polymer Chemistry, 1993
- Retention and enantioselectivity of racemic solutes on a modified ovomucoid-bonded columnJournal of Chromatography A, 1992
- Über die Anwendung von enzymanalog gebauten Polymeren zur RacemattrennungAngewandte Chemie, 1972