Use of 99Tcm Radionuclides to Show Nephrotoxicity of Cyclosporin a in Transplanted Kidneys
- 1 January 1987
- journal article
- research article
- Published by SAGE Publications in Acta Radiologica
- Vol. 28 (1) , 59-61
- https://doi.org/10.1177/028418518702800112
Abstract
In 60 patients, 99Tcm pertechnetate or 99Tcm methylene diphosphonate was injected through an arm vein within 36 h after renal transplantation and repeated 24 or 48 h later. Thirty-one were treated with azathioprine and prednisone, 27 of the grafts had a well-defined peak on the histograms similar to that from the iliac artery histograms at both examinations. In contrast, of the 29 patients treated with cyclosporin A, only 5 of the grafts had a well-defined peak at both examinations. The difference is highly significant. Treatment with cyclosporin A causes a decrease in renal blood flow in the days immediately after transplantation.Keywords
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