Leukocyte Alkaline Phosphatase Isoenzymes in Down’s Syndrome

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Abstract
Leukocyte alkaline phosphatase from normal children and from trisomy 21 Down’s syndrome children was characterized by means of acrylamide gel disc electrophoresis, neuraminidase sensitivity, heat and urea inactivation and L-phenylalanine inhibition. The leukocyte enzyme from normal and mongoloid children showed the same biophysical and biochemical characteristics. These findings suggested that the increase in activity of leukocyte alkaline phosphatase in Down’s syndrome is not related to qualitative changes in the enzyme molecule.

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