Glycosylation changes during differentiation of the murine uterine epithelium

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Abstract
In mouse uterine luminal epithelium (LE) several terminal carbohydrate structures are regulated by ovarian steroids and show stage-specific expression during early pregnancy. We have demonstrated that expression of H-type-1 antigen (Fucα1-2Galβ1-3GlcNAcβ1-) is regulated by oestrogenic stimulation of α-2fucosyltransferase (fut1) mRNA levels in LE. H-type-1 expression is high after ovulation but becomes negligible after implantation. In contrast, NeuNAcα2-3Galβ1-, and specifically sialyl Le-x (NeuAcα2,3Galβ1,4-[Fucα1-3]GlcNAcβ1-), is stimulated by progesterone. It is not expressed on LE after ovulation but is expressed maximally on apical LE at the time of and after implantation. However, mRNA levels for 4 out of 5 known Gal/GalNAc α2-3sialyltransferases appear not to change in LE during early pregnancy, suggesting an alternative level of control.

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