Localization of action of chlorothiazide in the nephron of the dog

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Abstract
Localization of the actions of chlorothiazide in dogs has been studied by the ‘stop-flow’ technique. The compound interfered with the reabsorption within the proximal segment of a portion of the filtered sodium chloride. In this activity it exhibited effects qualitatively similar to those of chlormerodrin, an organic mercurial diuretic. In addition, chlorothiazide diminished H+ and NH4+ excretion while augmenting K+ secretion within the distal segment. These are typical of the carbonic anhydrase inhibitory effects observed previously with acetazoleamide and presented in this study with dichlorphenamide. Probenecid blocked the proximal secretion of chlorothiazide but did not alter its actions on ion transport.

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