Species differences of galactose metabolism in erythrocytes

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Abstract
Keiding S. Species differences of galactose metabolism in erythrocytes. Scand J Clin Lab Invest 1985; 45: 697–700. Galactose metabolism was studied in suspensions of erythrocytes from man, rat, ox and pig at approximate steady-state galactose concentrations from 0.1–6.5 mmol/1. There was no detectable galactose elimination in pig erythrocytes. In the three other species the elimination followed saturation kinetics with the maximal elimination rate, Vmax, being 8.0 μmolmin-1 -l-1 human erythrocytes; 12 μmol-mirr-1l-1 rat erythrocytes; 2.4 μmol-min-1l-1 bovine erythrocytes. The half saturation concentration, Km, was about the same in all three species, around 0.2 mmol/1. If similar in vivo, erythrocyte metabolism of galactose is not of major quantitative importance compared to the hepatic metabolism in the species examined.

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