The Distribution of Ammonia between Extracellular and Intracellular Compartments of the Rat Brain
- 1 January 1975
- journal article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 48 (1) , 33-37
- https://doi.org/10.1042/cs0480033
Abstract
1. The distribution of ammonia between extra- and intra-cellular compartments of the brain was evaluated in anaesthetized rats exposed to sustained hyperammonaemia and superimposed acute hypo- or hyper-capnia. 2. It is concluded that the concentration gradient for ammonia between arterial plasma and cerebrospinal fluid (CSF) cannot be explained by pH-dependent non-ionic diffusion of ammonia. A continuous uptake by the brain tissue of ammonia from the CSF is postulated and possible mechanisms are discussed.Keywords
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