Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes
- 1 July 1998
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 81 (3-4) , 208-212
- https://doi.org/10.1159/000015032
Abstract
We constructed a comparative cytogenetic map of 25 functional genes in mouse and rat X chromosomes by direct R-banding fluorescence in situ hybridization. Nineteen and 22 out of the 25 genes, which have been mapped on the human X chromosome, were newly localized to mouse and rat X chromosomes, respectively. Twenty-two additional genes were integrated in the rat-mouse-human comparative map of the X chromosome in this study. Comparison of the gene order indicated the presence of four chromosome segments with conserved linkage homology between mouse and rat X chromosomes, suggesting that a minimum of four chromosomal inversion events occurred between mouse and rat X chromosomes during the evolution of the two species. Four chromosome segments with conserved linkage homology were found between human and rat X chromosomes.Keywords
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