Total HCV core antigen assay: A new marker of hepatitis C viremia for monitoring the progress of therapy
- 4 March 2003
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 70 (1) , 27-30
- https://doi.org/10.1002/jmv.10355
Abstract
The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen. J. Med. Virol. 70: 27–30, 2003.Keywords
Funding Information
- Center for Bio-Molecular Interdisciplinary Studies and Industrial Applications (CISI), Center of Excellence, University of Milan
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