Inhibition of Hepatic Glutathione S-Transferases by a Major Endogenous Ligand Substance Present in Uremic Serum
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 49 (4) , 281-283
- https://doi.org/10.1159/000185076
Abstract
A major endogenous ligand substance present in uremic serum, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, inhibited the in vitro activity of bovine and rat liver glutathione S-transferases. Our results suggested that endogenous ligand substances retained in uremic serum have some toxic activities other than the inhibition of drug binding to serum protein observed in uremia.This publication has 8 references indexed in Scilit:
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