Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin
Open Access
- 1 April 1983
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 78 (4) , 665-669
- https://doi.org/10.1111/j.1476-5381.1983.tb09418.x
Abstract
1 Wheal and flare reactions are described following intradermal injections of somatostatin, vasoactive intestinal polypeptide, substance P and histamine in normal human forearm skin. Bombesin failed to produce a significant wheal and flare. 2 Pretreatment of skin with capsaicin in all cases dramatically inhibited the flare but not the wheal. This result is in accord with the hypothesis that capsaicin blocks the effector side of the axon reflex, perhaps by depleting nerve terminals of vasodilatory peptide(s).This publication has 31 references indexed in Scilit:
- Distribution of bombesin, somatostatin, substance-P and vasoactive intestinal polypeptide in feline and porcine skinLife Sciences, 1983
- Intrathecal substance P and somatostatin in rats: Behaviors indicative of sensationPeptides, 1982
- Bombesin-like peptides in rat spinal cord: Biochemical characterization, localization and mechanism of releaseLife Sciences, 1981
- Increase in tissue concentrations of histamine and 5-hydroxytryptamine following capsaicin treatment of newborn ratsLife Sciences, 1981
- Peptidergic neuronesNature, 1980
- Substance P as a Transmitter CandidateAnnual Review of Neuroscience, 1980
- AUTONOMIC NEUROEFFECTOR JUNCTIONS—REFLEX VASODILATATION OF THE SKINJournal of Investigative Dermatology, 1977
- SUBSTANCE P: A NATURALLY OCCURRING TRANSMITTER IN HUMAN SPINAL CORDThe Lancet, 1976
- The Correlation between the Stimulation Frequency and the Dilator Response Evoked by ‘Antidromic’ Excitation of the Thin Afferent Fibres in the Dorsal RootsActa Physiologica Scandinavica, 1953