Provocation tests versus 24-h pH and pressure measurements

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Abstract
The diagnosis of the oesophageal origin of non-cardiac chest pain is still a matter of controversy. This review discusses the diagnostic accuracy of oesophageal provocation tests, such as acid perfusion, edrophonium and balloon distension, in comparison with 24-h intra-oesophageal pH and pressure recordings. It also discusses how these various tests relate to known underlying mechanisms of oesophageal chest pain: acid reflux, oesophageal dysmotility or a combination of both.

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