Mediation of central prostaglandin effects by serotoninergic neurons
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 64 (1) , 113-120
- https://doi.org/10.1007/bf00427355
Abstract
Ten days after administration of 5,6-dihydroxytryptamine, which causes degeneration of central serotoninergic neurons, the depressive behavioral effects of PGF2α and PGE2 were evidently inhibited. Central chemical serotoninectomy abolished the hyperthermic and hypertensive effects of PGF2α, but only slightly affected those of PGE2. It is concluded that serotoninergic neurons mediate the depressive behavioral action of both PGF2α and PGE2. They also mediate the hyperthermic and hypertensive action of PGF2α but not of PGE2. This suggests that these prostaglandins have different central modes of action.This publication has 35 references indexed in Scilit:
- The influence of β-blocking agents on the kinin system in rat plasmaJournal of Pharmacy and Pharmacology, 1978
- Model of Central Chemical ‘Serotoninectomy’ in MicePharmacology, 1978
- Prostaglandin-sensitive neurones in cat hypothalamus: relation to thermoregulation and to biogenic aminesCanadian Journal of Physiology and Pharmacology, 1977
- Body temperature responses at different ambient temperatures following injections of prostaglandin E1 and noradrenaline into the brainPharmacology Biochemistry and Behavior, 1976
- Pyrogen and prostaglandin fever in the rabbit—II: Effects of noradrenaline depletion and adrenergic receptor blockadeNeuropharmacology, 1975
- Effect of Central Cholinergic Blockade on the Hyperthermia Evoked by Prostaglandin E1 Injected Into the Rostral Hypothalamus of the RatCanadian Journal of Physiology and Pharmacology, 1975
- Biochemical and behavioural alterations following 5,6-dihydroxytryptamine administration into brainNeuropharmacology, 1974
- Long-term recovery of serotonin concentrations in the rat CNS following 5,6-dihydroxytryptamineLife Sciences, 1973
- Effects of 5,6-dihydroxytryptamine on nerve terminal serotonin and serotonin uptake in the rat brainBrain Research, 1973
- Inhibition by prostaglandin E1 of noradrenaline release and of effector response to nerve stimulation in the cat spleenLife Sciences, 1969