Intranasal Instillation of Oxytocin Increases Insulin and Glucagon Secretion

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Abstract
I.v. administered oxytocin increased plasma insulin and glucagon levels. To determine whether the same effects could be obtained by nonparenteral routes of administration, oxytocin was given by nasal instillation in normal conscious dogs. Plasma glucose, insulin and glucagon levels all increased to levels which previously caused increased glucose production and utilization. Vasopressin infusion had no effect on these measurements. This is the 1st report of the effectiveness of oxytocin to evoke insulin and glucagon secretion by the nasal route of administration.

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