Cyclic 3′,5′-Adenosine Monophosphate Phosphodiesterase Produced by the Slime Mold Dictyostelium discoideum
- 5 July 1968
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 161 (3836) , 57-59
- https://doi.org/10.1126/science.161.3836.57
Abstract
An enzyme that hydrolyzes cyclic ',5'-adenosine monophosphate to 5'-adenosine monophosphate was found in the culture medium of the cellular slime mold Dictyostelium discoidum. The enzymatic activity shows a pH optimum of 7.5, and magnesium is required for maximum activity. The enzyme is not inhibited by caffeine. It has a Michaelis-Menten constant of 2 x 10-3M and its molecular weight is around 300,000.Keywords
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