Immunoenzymehistochemical detection of fibrin microthrombi during disseminated intravascular coagulation in rats
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Histochemistry and Cell Biology
- Vol. 57 (2) , 97-105
- https://doi.org/10.1007/bf00496674
Abstract
In tissue of rats with disseminated intravascular coagulation, fibrin microthrombi can be sensitively detected by immunohistochemical methods, using antisera against rat fibrinogen or fibrin monomer. An indirect immunoperoxidase procedure on paraplast-embedded sections yields best results with regard to the morphology of the thrombi and their localization in the tissue. Only fibrillar immunoreactive material, oriented lengthwise in the vessels, should be regarded as microthrombi formed in vivo.Keywords
This publication has 23 references indexed in Scilit:
- Localization of lipase-like immunoreactivity in porcine adipose, aortic and myocardial tissueAtherosclerosis, 1977
- In Vivo Behaviour of Homologous Urea‐Soluble 131I‐Fibrin and 125I‐Fibrinogen in Rabbits: the Effect of Fibrinolysis InhibitionBritish Journal of Haematology, 1976
- Rat Liver Macrophages will not Phagocytose Fibrin during Disseminated Intravascular CoagulationPathophysiology of Haemostasis and Thrombosis, 1976
- The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibodyJournal of Clinical Pathology, 1974
- Identification of intrarenal fibrin depositionJournal of Clinical Pathology, 1973
- INHIBITION OF ERYTHROCYTE PSEUDOPEROXIDASE ACTIVITY BY TREATMENT WITH HYDROGEN PEROXIDE FOLLOWING METHANOLJournal of Histochemistry & Cytochemistry, 1972
- A comparison of tinctorial and immunohistological methods for the detection of fibrinoid change and fibrin deposition in the kidneyJournal of Molecular Histology, 1972
- Gelation of Soluble Fibrin in Plasma by EthanolScandinavian Journal of Haematology, 1966
- THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966
- Disseminated fibrin thrombo‐embolism among stillbirths and neonatal deathsThe Journal of Pathology and Bacteriology, 1965