Addition of Buserelin to human menopausal gonadotrophins in patients with failed stimulations for IVF or GIFT
- 1 October 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 3 (suppl 2) , 35-38
- https://doi.org/10.1093/humrep/3.suppl_2.35
Abstract
The combined therapy of a gonadotrophin-releasing hormone agonist (GnRH) D-Ser(TBU)6-EA10-LHRH (Buserelin) and human menopausal gonadotrophins (HMG) for ovarian stimulation for in-vitro fertilization and gamete intra-Fallopian transfer was evaluated during 84 cycles. All women selected for this therapy had previously failed stimulations with clomiphene citrate/HMG. The GnRHa prevented spontaneous luteinizing hormone surges and premature luteinization in all patients. After addition of the agonist to HMG, the cancellation rate dropped from 17 to 7% and improved the results in 72.6% of the cycles. Twenty-six per cent of the started cycles resulted in a pregnancy. Eighteen healthy children were born at term.Keywords
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