Contrasting Effects of Testicular and Ovarian Steroids upon Muscarinic Binding Sites in the Brain
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 34 (5) , 250-258
- https://doi.org/10.1159/000138276
Abstract
In adult rats, testosterone increases the saturation binding capacity of hypothalamic and amygdaloid membrane fragments for the muscarinic antagonist, N-methyl scopolamine. In contrast, both estradiol and progesterone decrease binding capacity. There are sexual differences in muscarinic binding capacity and these are dependent upon perinatal exposure to androgens.Keywords
This publication has 10 references indexed in Scilit:
- Alteration of muscarinic binding in specific brain areas following estrogen treatmentBrain Research, 1982
- Oestrogen induction of progestin receptors in the rat brain and pituitary gland: quantitative and kinetic aspectsJournal of Endocrinology, 1982
- An epizootic of lymphoma in northern pike, Esox lucius L., from the Åland Islands of FinlandJournal of Fish Diseases, 1982
- Serotonin Receptor Modulation by Estrogen in Discrete Brain NucleiNeuroendocrinology, 1982
- Molecular regulation of receptors: interaction of beta-estradiol and progesterone with the muscarinic system.Proceedings of the National Academy of Sciences, 1981
- Temporal relationship between cell nuclear progestin receptor levels and sexual receptivity following intravenous progesterone administrationBrain Research, 1981
- The character of the muscarinic receptors in different regions of the rat brainProceedings of the Royal Society of London. B. Biological Sciences, 1980
- BINDING OF AGONISTS TO BRAIN MUSCARINIC RECEPTORS1978
- BINDING OF ANTAGONISTS TO BRAIN MUSCARINIC RECEPTORS1978
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951