Activities of Proscillaridin A in Thoracic Duct Lymph after Single Oral Doses in Man

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Abstract
The possibility that orally administered proscillaridin after absorption was transported by the lymph to the systemic circulation was studied by analyzing the concentrations of the glycoside in thoracic duct lymph of 2 patients with thoracic duct drainage. Plasma and lymph concentrations were measured by 86Rb-technique and lymph was collected at various intervals for 24 h. The proscillaridin activity in thoracic duct lymph was low and followed closely that in the plasma. During the sampling period, a total of 300 ng and 240 ng, respectively, was recovered in the lymph, corresponding to < 0.03% of the administered dose. Proscillaridin was probably not transported by the thoracic duct lymph.

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