Automated sequence reading and analysis
- 11 March 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (5) , 1847-1856
- https://doi.org/10.1093/nar/16.5.1847
Abstract
We report on a system developed by Bio-Rad Laboratories, INC. which combines automated reading of DNA sequencing autoradiograms with comprehensive software for shotgun overlapping of the readings, analysis of the sequences derived and searching of databases. Reading is accomplished using a high speed optical scanner and pattern recognition software operating on a personal computer. Overlapping, analysis and database searching software each incorporate significant advances over prior systems.Keywords
This publication has 15 references indexed in Scilit:
- Automatic reading of DNA sequencing gel autoradiographs using a large format digital scannerNucleic Acids Research, 1986
- A computer program to enter DNA gel reading data into a computerNucleic Acids Research, 1984
- Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencingNucleic Acids Research, 1982
- An interactive graphics program for comparing and aligning nucleic acid and amino acid sequencesNucleic Acids Research, 1982
- A computer program to search for tRNA genes.1980
- A mew computer method for the storage and manipulation of DNA gel reading dataNucleic Acids Research, 1980
- A strategy of DNA sequencing employing computer programsNucleic Acids Research, 1979
- Further procedures for sequence analysis by computerNucleic Acids Research, 1978
- Sequence data handling by computerNucleic Acids Research, 1977
- A general method applicable to the search for similarities in the amino acid sequence of two proteinsJournal of Molecular Biology, 1970