CERULOPLASMIN LEVELS AND ERYTHROCYTE SUPEROXIDE DISMUTASE ACTIVITY IN SMALL PRETERM INFANTS DURING THE EARLY ANEMIA OF PREMATURITY

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Abstract
Ceruloplasmin plasma levels and erythrocyte superoxide dismutase activity were studied in appropriate for gestational age preterm infants (birth wt .ltoreq. 1500 g) during the first 10 wk of life. Preterm infants had significantly lower ceruloplasmin concentrations in cord blood than term infants, the mean level in the preterm infants being 0.07 g/l. At 1 wk of age ceruloplasmin levels had risen significantly, whereupon a fall occurred at 2 wk of age. Ceruloplasmin concentrations increased slowly and progressively from 4 wk of age. The low ceruloplasmin concentration during the early anemia of prematurity seems not to interfere with Fe mobilization. The superoxide dismutase activity/g Hb in cord blood erythrocytes from normal term infants was significantly lower than that of red blood cells from adults. When the activity was expressed per erythrocyte no difference was found. The normochromic macrocytic red blood cells of the neonate most likely explain this discrepancy. The erythrocyte superoxide dismutase activity of the preterm infants did not change from birth until 10 wk of age and the levels seemed adequate judged from the levels found in red blood cells from adults and cord blood from term infants. Neither ceruloplasmin nor erythrocyte superoxide dismutase activity seem to play a role in the etiology of the early anemia of prematurity.

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