ANTIBODY PRODUCTION IN MILK SERUM AFTER VIRUS INSTILLATION OF GOAT MAMMARY GLAND: I. RESPONSES TO INFLUENZA VIRUS, MUMPS VIRUS, AND ADENOVIRUS 3

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Abstract
The study reported in this article relates to the instillation of three viruses into the mammary glands of goats. The PR8 strain of influenza A virus (Myxovirus influenzae) and mumps virus (Myxovirus parotidis) replicated in the gland and antibody formation occurred in a few days. Adenovirus 3 failed to replicate but repeated instillations led to antibody synthesis.The antibody of each was concentrated. Influenza PR8 was found to possess two activities, complement fixing which gave reactions with all strains of type A examined, and neutralizing antibody which was specific for the PR8 strain.In the case of adenovirus 3, the milk contained neutralizing antibody only. It was specific for adenovirus 3.Mumps virus replicated in the gland and antibody formation followed. The properties of this antibody have not been studied.