Amino Acid Sequence of the Blood Group Mg-Specific Major Human Erythrocyte Membrane Sialoglycoprotein
- 1 January 1981
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 362 (1) , 81-86
- https://doi.org/10.1515/bchm2.1981.362.1.81
Abstract
The structure of the N-terminal 21 residues of the blood group Mg-specific major human erythrocyte membrane sialoglycoprotein was investigated, using tryptic MgM peptides and secondary fragments prepared by staphylococcal V8 protease treatment. The sequence Leu-Ser-Thr-Asn-Glu was obtained for the N-terminal 5 residues. The Mg gene appears to have evolved from a Thr .fwdarw. Asn mutation of an N allele. This alteration prevented the glycosylation of the amino acids at the 2nd and 3rd positions.This publication has 17 references indexed in Scilit:
- Structure of the Ss Blood Group Antigens, II. A Methionine/Threonine Polymorphism within the N-terminal Sequence of the Ss GlycoproteinHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1980
- Structure of the Ss Blood Group Antigens. I. Isolation of Ss-Active Glycopeptides and Differentiation of the Antigens by Modification of MethionineHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1980
- The role of sialic acid in the expression of human MN blood group antigens.Journal of Biological Chemistry, 1979
- Structural polymorphism within the amino-terminal region of MM, NN, and MN glycoproteins (glycophorins) of the human erythrocyte membraneProceedings of the National Academy of Sciences, 1978
- STUDIES ON THE MEMBRANE GLYCOPROTEIN DEFECT OF En (a‐) ERYTHROCYTESInternational Journal of Immunogenetics, 1978
- THE DEFECT OF Mk ERYTHROCYTES AS REVEALED BY SODIUM DODECYLSULPHATE‐POLYACRYLAMIDE GEL ELECTROPHORESIS*International Journal of Immunogenetics, 1977
- The amino acids of M and N blood group glycopeptides are differentBiochemical and Biophysical Research Communications, 1977
- Biosynthesis of blood group active glycoproteins: A peptidyl: α-N-acetylgalactosaminyltransferase from human submaxillary gland and stomach mucosal tissueBiochemical and Biophysical Research Communications, 1970
- Glycoprotein biosynthesis: Studies on the receptor specificity of the polypeptidyl: N-acetylgalactosaminyl transferase from bovine submaxillary glandsArchives of Biochemistry and Biophysics, 1968
- IUPAC-IUB Commission on Biochemical Nomenclature A One-Letter Notation for Amino Acid Sequences1–3Published by Elsevier ,1968