LASMA AMINO ACID CONCENTRATIONS AND 35S-DISTRIBUTION IN THE SOW AND FETUS FOLLOWING INJECTION OF 35S-METHIONINE

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Abstract
Following maternal intravenous injection of 1.6 mg/kg body weight 35S-methionine, only a small proportion of the administered 35S reached fetal circulation. Fetal liver uptake of 35S was much less than that of maternal liver. A transient minor increase in the maternal plasma methionine concentration was not reflected in fetal plasma. Isoleucine, leucine, valine and phenylalanine were at lower concentrations in fetal plasma than in maternal plasma, with threonine, glutamic acid, proline, glycine, alanine and tyrosine generally higher in fetal blood. The proportion of 35S reaching the fetal circulation appeared to be cleared at a slower rate than the 35S from maternal plasma. The placenta appeared to function as an effective buffer against transient minor changes in the maternal plasma methionine concentration. The extent of the buffering capacity of the placenta against maternal plasma amino acid fluctuations requires further investigation.
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