Persistent Ashen-Gray Maculae and Freckles Induced by Long-Term PUVA Treatment
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Dermatology
- Vol. 166 (6) , 281-286
- https://doi.org/10.1159/000249891
Abstract
Persistent ashen-gray maculae 5–7 mm in diameter and freckles developed after prolonged PUVA therapy of psoriasis. Histopathology of maculae showed extensive collections of melanophages in the upper dermis. The melanocytes were strongly stimulated at the site of the freckles. The number of melanosomes, mitochondria, endoplasmic reticulum and dendrites were increased. Pathological features such as large amounts of lipid droplets and lysosome-melanosome complexes were also found within the melanocytes.Keywords
This publication has 2 references indexed in Scilit:
- Hyperpigmentation and Hypopigmentation of the Skin after Long Term PUVA TherapyJournal of Cutaneous Pathology, 1981
- Long-term photochemotherapy: histopathological and immunofluorescence observations in 243 patientsBritish Journal of Dermatology, 1980