TREATMENT OF METASTATIC RENAL-CANCER WITH IFOSFAMIDE AND MESNUM WITH AND WITHOUT IRRADIATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 64  (10-1) , 1103-1108
Abstract
Ifosfamide (50-60 mg/kg of body weight, days 1-5) and mesnum (10-12 mg/kg body wt, days 1-5) were given to 15 patients with measurable metastatic renal cancer. This treatment was repeated on day 29. Six of these 15 patients received irradiation to some of the metastatic areas. There was 1 partial remission among 11 evaluable patients after 2 ifosfamide courses. The partial remission was seen in a metastatic area treated with low-dose irradiation prior to the 1st ifosfamide course. Two cases of early death and 2 cases of toxic death (urotoxicity) were observed. The main hematologic complication was moderate to severe leukopenia. Previously reported high response rates to ifosfamide treatment of renal cancer could not be confirmed.

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