Chaos in DNA partition during the last mitoses of the proliferative life‐span of human fibroblasts
- 23 January 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 358 (2) , 126-128
- https://doi.org/10.1016/0014-5793(94)01407-r
Abstract
We have followed with autoradiography the course of DNA synthesis and with cytofluorometry the partition of DNA during mitosis, through the different phases of the life-span of human fibroblasts. Towards the end of the proliferative potential of the cell population, DNA synthesis was disturbed during the late part of the S period. The DNA content of metaphases and of anaphases had a normal Gaussian distribution during the whole proliferative life-span of the cell population. At the very end, however, when cells entered the post-mitotic phase, the distribution of DNA content deviated from the normal Gaussian probability, becoming significantly skewedKeywords
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