SUPPRESSION OF HISTAMINE-INDUCED ADRENOCORTICOTROPIC HORMONE-RELEASE BY ANTIHISTAMINES AND ANTI-DEPRESSANTS
- 1 January 1982
- journal article
- research article
- Vol. 222 (3) , 583-588
Abstract
The antihistaminic activity of many antidepressant drugs is well documented in vitro but has not been investigated as thoroughly in vivo. In the course of an investigation of the roles of H1 and H2 receptors in histamine-induced ACTH release in rats, it was observed that several antidepressants were potent inhibitors of this response. Male Sprague-Dawley rats were injected with test drugs and then with histamine or histamine agonists. Serum ACTH concentrations were determined by radioimmunoassay. ACTH secretion was induced by both H1 and H2 receptor stimulation. Histamine-induced ACTH release was markedly attenuated by several H1 antihistamines, whereas the H2 antagonists were not as effective. The antidepressants imipramine, doxepin, mianserin, desipramine and amitriptyline suppressed histamine-induced ACTH release. Iprindole and the antianxiety agent diazepam were without effect. ACTH release induced by histamine agonists was also diminished by pretreatment with some of these blocking agents.This publication has 19 references indexed in Scilit:
- Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.Proceedings of the National Academy of Sciences, 1978
- Nycthemeral rhythm in adrenal responsiveness to ACTHAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1978
- Brain histamine receptors as targets for antidepressant drugsNature, 1978
- Plasma corticosterone and brain catecholamines in stress: Effect of psychotropic drugsPharmacology Biochemistry and Behavior, 1977
- SOME ACTIONS OF CHLORPROMAZINEBritish Journal of Pharmacology and Chemotherapy, 1956
- INHIBITION OF THE RELEASE OF CORTICOTROPHIN FROM THE HYPOPHYSIS BY CHLORPROMAZINEActa Endocrinologica, 1956
- Effect of Histamine, Hog Vasopressin, and Corticotropin-Releasing Factor (GRF) on AGTH Release in vitroExperimental Biology and Medicine, 1956
- Mechanisms by Which Histamine Stimulates ACTH Release in RatsAmerican Journal of Physiology-Legacy Content, 1954
- DUAL CONTROL OF ADRENOCORTICOTROPHIN RELEASE*Endocrinology, 1951
- THE RAPIDITY OF THE ADRENOCORTICOTROPIC RESPONSE OF THE PITUITARY TO THE INTRAVENOUS ADMINISTRATION OF HISTAMINE123Endocrinology, 1951