Detection of oxygen-derived radicals in biological systems using electron spin resonance.
Open Access
- 1 December 1994
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 102 (suppl 10) , 33-36
- https://doi.org/10.1289/ehp.94102s1033
Abstract
Oxygen-centered radicals, particularly the hydroxyl and superoxide radicals, have been postulated in many biochemical reactions and have been implicated in many adverse reactions in vivo. This article begins with a review of spin-trapping detection of oxygen-centered radicals in vitro and concludes with a presentation of our approach to the detection of the hydroxyl radicals in models of acute iron and copper poisoning.Keywords
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