Effects of Triethyltin on Different ATPases, 5′-Nucleotidase and Phosphodiesterases in Grey and White Matter of Rabbit Brain and their Relation with Brain Edema

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Abstract
In our studies, we tried to decide whether several enzymes of cortical grey and subcortical white matter of rabbit brain might be influenced differently by triethyltin (TET) and by other organometallic compounds. We performed neurochemical studies on rough mitochondrial and microsomal fractions. Despite differences in distribution and in specific activities, the inhibition patterns of the ATPases, nucleotidases and phosphodiesterases of grey and white matter in vitro were similar. Mitochondrial Mg2+-ATPase was inhibited more strongly than Na+,K+-ATPase. The activity of 3’,5’-cyclic AMP-phosphodiesterase was inhibited as strongly as the Na+,K+-ATPase activity. The activity of myelin-specific 2’,3’-cyclic AMP-phosphodiesterase was not influenced whereas the 5’-nucleotidase activity was stimulated by the organometallic compounds. The content of TET in the white matter could not be related with the TET edema and was somewhat lower than in the grey matter. The results obtained point towards a general conformational change in membrane structures by organometallic compounds, which might result after in vivo administration with TET in brain edema in the white matter.

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