Phrenic Nerve Pacing for the Treatment of Central Hypoventilation Syndrome - State of the Art and Case Report

Abstract
The application of phrenic nerve pacing is an effective method of respiratory support in adults with certain forms of acquired failure of automatic ventilation. The experience with one infant suffering from congenital central hypoventilation (Ondine's syndrome) is summarized in this report. Stimulation electrodes were implanted on the thoracic portion of each phrenic nerve. After a cumbersome period of intensive medical care and conditioning of the phrenic nerve-diaphragm system, the patient could be weaned off the respirator. Severe upper airway obstruction, however, required tracheostomy. Bilateral simultaneous pacing has been effectíve now for more than 2 years providing the desired normal ventilation during sleep. The state of the art of phrenic nerve pacing is described.

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