Del cell line: A “malignant histiocytosis” CD30 + T(5;6)(Q35;P21) cell line

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Abstract
A new cell line DEL, established in vitro, was isolated from a pleural effusion of a boy who died of malignant histiocytosis. Its principal characteristics are: strong positivity with monoclonal antibodies (MAbs) to CD25, CD30, CD45R, KiM7, EMA, HLA CI I and II; constant presence of acid phosphatase, ANAE, α-anti-trypsin, α-anti-chymotrypsin and NBT reduc-tase activity; rearrangement of the immunoglobulin heavychain gene (JH) and a germ-line configuration of the T-chain gene; and finally a translocation between chromosomes 5–6 with a breakpoint in 5q35. The DEL cell line is appropriate for studying the role of the 5q localized c-fms oncogene and of the genes of the mononuclear phagocyte growth factor (CSFI) and of their receptors in the dynamics and etiology of malignant hemopathies associated with a 5q35 breakpoint.
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