DEFECTIVE LIFE-CYCLE AND LOW ANTIBIOTIC PRODUCTION IN SUBMERGED CULTURES OF STREPTOMYCES FRADIAE .1. BIOCHEMICAL CHARACTERIZATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (4) , 299-306
Abstract
The life cycle of a S. fradiae strain producing high amounts of neomycin under industrial conditions was investigated in liquid soybean medium where the production of antibiotic proved to be comparatively low. The changes occurring in the main macromolecular components and the enzyme activities of the mycelium during the life cycle and cytological observations proved that there was a block in the normal process of reproductive differentiation and a lack of exocellular alkaline phosphatase activity was found.