A Suggested Columnar Cell Morphological Equivalent of Squamous Carcinoma In Situ with Early Stromal Invasion

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Abstract
Cervical squamous carcinoma in situ with early stromal invasion has recently been defined as a strict histologic entity. Two cases of extensive classical adenocarcinoma in situ of the uterine cervix and one of very early invasive adenocarcinoma are reported that showed foci indistinguishable from squamous early stromal invasion arising directly from unequivocally glandular in situ malignant foci. This finding is further evidence in support of the theory that glandular and squamous intraepithelial neoplasia in the cervix are closely related conditions, possibly with a common origin in the subcolumnar reserve cell.