What is the mechanism of phosphoryl transfer in protein kinases? A hybrid quantum mechanical/molecular mechanical study
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 1,p. 79-80
- https://doi.org/10.1039/a808955h
Abstract
Hybrid QM/MM studies suggest that the conserved aspartate in protein kinases is not protonated during the phosphoryl transfer reaction, and thus does not act as a general base.Keywords
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