Sodium n-Butyrate Causes Reversible Decrease in Condensed Chromatin Clumps in HeLa Cells
- 1 September 1979
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 161 (4) , 543-545
- https://doi.org/10.3181/00379727-161-40593
Abstract
There is a marked decrease in condensed chromatin clumps in HeLa cells treated with sodium n-butyrate for 24 hr. This change is rapidly reversible, with chromatin clumps reappearing 15 min after removal of the n-butyrate. These reversible morphological changes are closely correlated with hyper-acetylation of histones in n-butyrate-treated cells, and may represent a morphological expression of the biochemical modification of histones.This publication has 7 references indexed in Scilit:
- Ultrastructural Concomitants of Sodium Butyrate-Enhanced Ectopic Production of Chorionic Gonadotropin and Its Alpha Subunit in Human Bronchogenic Carcinoma (ChaGo) CellsJNCI Journal of the National Cancer Institute, 1979
- Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences.Proceedings of the National Academy of Sciences, 1978
- The effect of sodium butyrate on histone modificationCell, 1978
- Sodium butyrate inhibits histone deacetylation in cultured cellsCell, 1978
- Reversible effects of Na-butyrate on histone acetylationBiochemical and Biophysical Research Communications, 1978
- Structure of chromatin containing extensively acetylated H3 and H4Cell, 1978
- Electron microscopic study of Herpesvirus saimiriVirology, 1977