Simultaneous Determination of Glycyrrhizin and Glycyrrhetic Acid in Plasma by High Speed Liquid Chromatography
Open Access
- 1 January 1978
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 98 (11) , 1545-1547
- https://doi.org/10.1248/yakushi1947.98.11_1545
Abstract
Simultaneous determination of glycyrrhizin (G) and glycyrrhetic acid (GA) in plasma was established by high-speed liquid chromatography. G and GA were extracted from plasma with 0.25 N NH4OH.cntdot.85% EtOH [ethanol]. The extracted sample containing indomethacin as an internal standard was analyzed on a reverse-phase column (SC-02-250) with gradient elution from water to 0.5% acetic acid-90% acetonitrile.Keywords
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