ALPHA-ADRENERGIC BLOCKING PROPERTIES OF DROPERIDOL ON ISOLATED BLOOD VESSELS OF THE DOG
Open Access
- 1 March 1977
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 49 (3) , 211-216
- https://doi.org/10.1093/bja/49.3.211
Abstract
Concentrations of droperidol which caused a shift to the right of the dose-response curve to nor-adrenaline in the pulmonary artery and the saphenous vein of the dog did not affect myogenic activation by K+; they did not inhibit spontaneous activity of portal-mesenteric veins. Droperidol inhibited the contractile response to nerve stimulation, but did not affect the evoked release of 3H-noradrenaline. These experiments indicate that the vasodilator properties of smaller doses of droperidol are a result of its ability to block alpha-adrenergic receptors.This publication has 0 references indexed in Scilit: