Plasma Prekallikrein (Fletcher Factor) Deficiency in a Patient With Chronic Lymphocytic Leukemia

Abstract
A patient is reported in whom plasma prekallikrein (Fletcher factor) deficiency and chronic lymphocytic leukemia were present. This most likely represents a coincidental occurrence but the markedly elevated peripheral blood lymphocyte count and the detection of the defect using ellagic acid are unique for Fletcher factor deficiency.