Stereochemistry of the dihydrouracil dehydrogenase reaction in metabolism of uracil to β-alanine
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 576-578
- https://doi.org/10.1039/c39830000576
Abstract
Samples of β-alanine stereospecifically labeled with deuterium in each of the four C–H bonds have been synthesized; these been used to show that, in the first step of uracil metabolism, the pyrimidine is reduced by dihydrouracil dehydrogenase with overall trans-addition of hydrogen at the si-face at C-6 and the si-face at C-5.Keywords
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