Feedback Inhibition by 6-Methylthioinosine 3',5'-Cyclic Monophosphate in Tumor Cells Resistant to the Nucleoside

1 December 1975

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 150 (3) , 578-580
https://doi.org/10.3181/00379727-150-39083

Abstract

The 3′, 5′-cyclic phosphate derivative (cMTIMP) of methylthioinosine (MTI) was shown to produce feedback inhibition of the de novo purine pathway in an Ehrlich ascites tumor subline resistant to MTI because of lack of adenosine kinase activity for the nucleoside analog.