Oxidative DNA damage: mechanisms, mutation, and disease
Top Cited Papers
- 8 May 2003
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 17 (10) , 1195-1214
- https://doi.org/10.1096/fj.02-0752rev
Abstract
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8-oxo-2′deoxyguanosine. This lesion has been the focus of intense research interest and been ascribed much importance, largely to the detriment of other lesions. The present work reviews the basis for the biological significance of oxidative DNA damage, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage. Given the plethora of (often contradictory) reports describing pathological conditions in which levels of oxidative DNA damage have been measured, this review critically addresses the extent to which the in vitro significance of such damage has relevance for the pathogenesis of disease. It is suggested that some shortcomings associated with biomarkers, along with ga...Keywords
Funding Information
- Food Standards Agency
This publication has 163 references indexed in Scilit:
- Monoclonal Antibody to Single-Stranded DNA: A Potential Tool for DNA Repair StudiesBiochemical and Biophysical Research Communications, 2001
- Oxidative stress in Alzheimer’s diseaseBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2000
- Synthesis and Cleavage of Oligodeoxynucleotides Containing a 5-Hydroxyuracil Residue at a Defined SiteChemical Research in Toxicology, 1997
- Molecular spectrum of mutations induced by 5-hydroxymethyl-2′-deoxyuridine in (CHO)-PL61 cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997
- Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesisEuropean Journal Of Cancer, 1996
- 1H,13C and15N nuclear magnetic resonance analysis and chemical features of the two main radical oxidation products of 2′-deoxyguanosine: oxazolone and imidazolone nucleosidesJournal of the Chemical Society, Perkin Transactions 2, 1996
- Detection of bulky DNA lesions in the liver of patients with Wilson's disease and primary haemochromatosisMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1995
- Monomeric Base Damage Products from Guanine, Adenine, and Thymine Induced by Exposure of DNA to Ultraviolet RadiationBiochemistry, 1995
- Thymidine Hydroperoxides: Structural Assignment, Conformational Features, and Thermal Decomposition in WaterJournal of the American Chemical Society, 1994
- Recognition of oxidized DNA bases by sera of patients with inflammatory diseasesFree Radical Biology & Medicine, 1993