Use of chiral lanthanide shift reagents for the nuclear magnetic resonance spectrometric determination of amphetamine enantiomers
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 107 (1274) , 544-549
- https://doi.org/10.1039/an9820700544
Abstract
Synthesised tris(D,D-dicampholylmethanato)europium(III)[Eu(dcm)3] and five commercially available chiral lanthanide shift reagents are used to resolve the nuclear magnetic resonance spectra of the enantiomeric C—CH3 protons in D- and L-amphetamine. The chemical shift difference between these enantiomeric protons induced by the six shift reagents are evaluated for their prospective use in enantiomeric identification and determination. The base-line resolution induced by Eu(dcm)3 renders the enantiomeric determination feasible without using any special quantitation technique.Keywords
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